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β –lapachone β –lap  (Macklin Inc)

 
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    Macklin Inc β –lapachone β –lap
    Schematic illustration of IR783‐stabilized nanodrugs to enhance anticancer immune response and promote breast cancer immunotherapy. A) The nanodrugs are formulated with IR783, β ‐lap, and CUDC101. IR783 serves as a stabilizer to form nanoparticles with two hydrophobic drug molecules based on small molecule self‐assembly. B) The nanodrugs can enter breast cancer cells through CAV‐1‐mediated endocytosis pathway and achieve synergistic anticancer effects from NQO1‐dependent oxidation therapy and CUDC101‐provoked epigenetic regulation. C) The nanodrugs can further promote DAMPs release and dendritic cell maturation to boost systemic antitumor immunity and inhibit both primary and distant tumor growth.
    β –Lapachone β –Lap, supplied by Macklin Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/%CE%B2+%E2%80%93lapachone+%CE%B2+%E2%80%93lap/pmc12140360-218-0-13?v=Macklin+Inc
    Average 90 stars, based on 1 article reviews
    β –lapachone β –lap - by Bioz Stars, 2026-07
    90/100 stars

    Images

    1) Product Images from "IR783‐Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation"

    Article Title: IR783‐Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation

    Journal: Advanced Science

    doi: 10.1002/advs.202415684

    Schematic illustration of IR783‐stabilized nanodrugs to enhance anticancer immune response and promote breast cancer immunotherapy. A) The nanodrugs are formulated with IR783, β ‐lap, and CUDC101. IR783 serves as a stabilizer to form nanoparticles with two hydrophobic drug molecules based on small molecule self‐assembly. B) The nanodrugs can enter breast cancer cells through CAV‐1‐mediated endocytosis pathway and achieve synergistic anticancer effects from NQO1‐dependent oxidation therapy and CUDC101‐provoked epigenetic regulation. C) The nanodrugs can further promote DAMPs release and dendritic cell maturation to boost systemic antitumor immunity and inhibit both primary and distant tumor growth.
    Figure Legend Snippet: Schematic illustration of IR783‐stabilized nanodrugs to enhance anticancer immune response and promote breast cancer immunotherapy. A) The nanodrugs are formulated with IR783, β ‐lap, and CUDC101. IR783 serves as a stabilizer to form nanoparticles with two hydrophobic drug molecules based on small molecule self‐assembly. B) The nanodrugs can enter breast cancer cells through CAV‐1‐mediated endocytosis pathway and achieve synergistic anticancer effects from NQO1‐dependent oxidation therapy and CUDC101‐provoked epigenetic regulation. C) The nanodrugs can further promote DAMPs release and dendritic cell maturation to boost systemic antitumor immunity and inhibit both primary and distant tumor growth.

    Techniques Used:

    Preparation and characterization of IR/Lap/CUDC NPs. A) Size distribution and transmission electron microscopy (TEM) image of IR/Lap/CUDC NPs (Scale bar: 200 nm). B) Zeta potential of IR/Lap/CUDC NPs. C) UV–vis absorption spectra of free β ‐lap, CUDC101, IR783, and IR/Lap/CUDC NPs. D) Stability test of IR/Lap/CUDC NPs under physiological conditions for 48 h. E) Size distribution changes of IR/Lap/CUDC NPs after H 2 O 2 incubation. F) Fluorescent spectra of IR/Lap/CUDC NPs with or without H 2 O 2 incubation. G) UV–vis absorption spectra of IR/Lap/CUDC NPs with or without H 2 O 2 incubation. H) Cell viability of 4T1 cells treated with gradient concentrations of free β ‐lap and CUDC101. I) Synergy score of free β ‐lap and CUDC101 in 4T1 cells at gradient concentrations calculated by the Highest Single Agent (HSA) model in SynergyFinder.
    Figure Legend Snippet: Preparation and characterization of IR/Lap/CUDC NPs. A) Size distribution and transmission electron microscopy (TEM) image of IR/Lap/CUDC NPs (Scale bar: 200 nm). B) Zeta potential of IR/Lap/CUDC NPs. C) UV–vis absorption spectra of free β ‐lap, CUDC101, IR783, and IR/Lap/CUDC NPs. D) Stability test of IR/Lap/CUDC NPs under physiological conditions for 48 h. E) Size distribution changes of IR/Lap/CUDC NPs after H 2 O 2 incubation. F) Fluorescent spectra of IR/Lap/CUDC NPs with or without H 2 O 2 incubation. G) UV–vis absorption spectra of IR/Lap/CUDC NPs with or without H 2 O 2 incubation. H) Cell viability of 4T1 cells treated with gradient concentrations of free β ‐lap and CUDC101. I) Synergy score of free β ‐lap and CUDC101 in 4T1 cells at gradient concentrations calculated by the Highest Single Agent (HSA) model in SynergyFinder. "NPs" shown in (E), (F), and (G) refers to IR/Lap/CUDC NPs.

    Techniques Used: Transmission Assay, Electron Microscopy, Zeta Potential Analyzer, Incubation



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    Image Search Results


    Schematic illustration of IR783‐stabilized nanodrugs to enhance anticancer immune response and promote breast cancer immunotherapy. A) The nanodrugs are formulated with IR783, β ‐lap, and CUDC101. IR783 serves as a stabilizer to form nanoparticles with two hydrophobic drug molecules based on small molecule self‐assembly. B) The nanodrugs can enter breast cancer cells through CAV‐1‐mediated endocytosis pathway and achieve synergistic anticancer effects from NQO1‐dependent oxidation therapy and CUDC101‐provoked epigenetic regulation. C) The nanodrugs can further promote DAMPs release and dendritic cell maturation to boost systemic antitumor immunity and inhibit both primary and distant tumor growth.

    Journal: Advanced Science

    Article Title: IR783‐Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation

    doi: 10.1002/advs.202415684

    Figure Lengend Snippet: Schematic illustration of IR783‐stabilized nanodrugs to enhance anticancer immune response and promote breast cancer immunotherapy. A) The nanodrugs are formulated with IR783, β ‐lap, and CUDC101. IR783 serves as a stabilizer to form nanoparticles with two hydrophobic drug molecules based on small molecule self‐assembly. B) The nanodrugs can enter breast cancer cells through CAV‐1‐mediated endocytosis pathway and achieve synergistic anticancer effects from NQO1‐dependent oxidation therapy and CUDC101‐provoked epigenetic regulation. C) The nanodrugs can further promote DAMPs release and dendritic cell maturation to boost systemic antitumor immunity and inhibit both primary and distant tumor growth.

    Article Snippet: β ‐lapachone ( β ‐lap), crystal violet, and DNase I were obtained from Macklin (Shanghai, China).

    Techniques:

    Preparation and characterization of IR/Lap/CUDC NPs. A) Size distribution and transmission electron microscopy (TEM) image of IR/Lap/CUDC NPs (Scale bar: 200 nm). B) Zeta potential of IR/Lap/CUDC NPs. C) UV–vis absorption spectra of free β ‐lap, CUDC101, IR783, and IR/Lap/CUDC NPs. D) Stability test of IR/Lap/CUDC NPs under physiological conditions for 48 h. E) Size distribution changes of IR/Lap/CUDC NPs after H 2 O 2 incubation. F) Fluorescent spectra of IR/Lap/CUDC NPs with or without H 2 O 2 incubation. G) UV–vis absorption spectra of IR/Lap/CUDC NPs with or without H 2 O 2 incubation. H) Cell viability of 4T1 cells treated with gradient concentrations of free β ‐lap and CUDC101. I) Synergy score of free β ‐lap and CUDC101 in 4T1 cells at gradient concentrations calculated by the Highest Single Agent (HSA) model in SynergyFinder.

    Journal: Advanced Science

    Article Title: IR783‐Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation

    doi: 10.1002/advs.202415684

    Figure Lengend Snippet: Preparation and characterization of IR/Lap/CUDC NPs. A) Size distribution and transmission electron microscopy (TEM) image of IR/Lap/CUDC NPs (Scale bar: 200 nm). B) Zeta potential of IR/Lap/CUDC NPs. C) UV–vis absorption spectra of free β ‐lap, CUDC101, IR783, and IR/Lap/CUDC NPs. D) Stability test of IR/Lap/CUDC NPs under physiological conditions for 48 h. E) Size distribution changes of IR/Lap/CUDC NPs after H 2 O 2 incubation. F) Fluorescent spectra of IR/Lap/CUDC NPs with or without H 2 O 2 incubation. G) UV–vis absorption spectra of IR/Lap/CUDC NPs with or without H 2 O 2 incubation. H) Cell viability of 4T1 cells treated with gradient concentrations of free β ‐lap and CUDC101. I) Synergy score of free β ‐lap and CUDC101 in 4T1 cells at gradient concentrations calculated by the Highest Single Agent (HSA) model in SynergyFinder. "NPs" shown in (E), (F), and (G) refers to IR/Lap/CUDC NPs.

    Article Snippet: β ‐lapachone ( β ‐lap), crystal violet, and DNase I were obtained from Macklin (Shanghai, China).

    Techniques: Transmission Assay, Electron Microscopy, Zeta Potential Analyzer, Incubation